KEGG   NETWORK: N00414
Entry
N00414                      Network                                

Name
HCMV US27 to CXCR4-GNB/G-PLCB-PKC signaling pathway
Definition
US27 -> Ca2+ -> PKC -> PTK2B -> (PTK2+BCAR1+CRK+PXN)
  Expanded
K22783 -> C00076 -> (5578,5579,5582) -> 2185 -> (5747+9564+1398+5829)
Class
nt06124 Chemokine signaling (viruses)
nt06167 Human cytomegalovirus (HCMV)
Type
Pathogen
Pathway
hsa05163  Human cytomegalovirus infection
Disease
H00368  Cytomegalovirus infection
Gene
5578  PRKCA; protein kinase C alpha
5579  PRKCB; protein kinase C beta
5582  PRKCG; protein kinase C gamma
2185  PTK2B; protein tyrosine kinase 2 beta
5747  PTK2; protein tyrosine kinase 2
9564  BCAR1; BCAR1, Cas family scaffold protein
1398  CRK; CRK proto-oncogene, adaptor protein
5829  PXN; paxillin
Perturbant
K22783 (US27)  US27; HCMV envelope glycoprotein US27
Metabolite
C00076  Calcium cation
Reference
  Authors
Tu CC, Arnolds KL, O'Connor CM, Spencer JV
  Title
Human Cytomegalovirus UL111A and US27 Gene Products Enhance the CXCL12/CXCR4 Signaling Axis via Distinct Mechanisms.
  Journal
J Virol 92:e01981-17 (2018)
DOI:10.1128/JVI.01981-17
Reference
  Authors
Arnolds KL, Lares AP, Spencer JV
  Title
The US27 gene product of human cytomegalovirus enhances signaling of host chemokine receptor CXCR4.
  Journal
Virology 439:122-31 (2013)
DOI:10.1016/j.virol.2013.02.006
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