KEGG   NETWORK: N00421
Entry
N00421                      Network                                

Name
HCMV IE2-86 to p21-cell cycle G1/S
Definition
IE2-86 -| CDKN1A
  Expanded
K22775 -| 1026
Class
nt06130 Cell cycle (viruses)
nt06167 Human cytomegalovirus (HCMV)
Type
Pathogen
Pathway
hsa05163  Human cytomegalovirus infection
Disease
H00368  Cytomegalovirus infection
Gene
1026  CDKN1A; cyclin dependent kinase inhibitor 1A
Perturbant
K22775 (IE2-86)  UL122; Cytomegalovirus viral transcription factor IE2
Reference
  Authors
Cinatl J Jr, Vogel JU, Kotchetkov R, Wilhelm Doerr H
  Title
Oncomodulatory signals by regulatory proteins encoded by human cytomegalovirus: a novel role for viral infection in tumor progression.
  Journal
FEMS Microbiol Rev 28:59-77 (2004)
DOI:10.1016/j.femsre.2003.07.005
Reference
  Authors
Michaelis M, Doerr HW, Cinatl J
  Title
The story of human cytomegalovirus and cancer: increasing evidence and open questions.
  Journal
Neoplasia 11:1-9 (2009)
DOI:10.1593/neo.81178
Reference
  Authors
Chen Z, Knutson E, Kurosky A, Albrecht T
  Title
Degradation of p21cip1 in cells productively infected with human cytomegalovirus.
  Journal
J Virol 75:3613-25 (2001)
DOI:10.1128/JVI.75.8.3613-3625.2001
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