KEGG   NETWORK: N00440
Entry
N00440                      Network                                

Name
HIV Vpu/Vif/Vpr to cGAS-STING signaling pathway
Definition
(Vpu,Vif,Vpr) -| IRF3
  Expanded
(K22890,K22892,K22202) -| 3661
Class
nt06134 CGAS-STING signaling (viruses and bacteria)
nt06161 Human immunodeficiency virus type 1 (HIV-1)
Type
Pathogen
Pathway
hsa05170  Human immunodeficiency virus 1 infection
Disease
H01563  HIV infection
Gene
3661  IRF3; interferon regulatory factor 3
Perturbant
K22890 (Vpu)  vpu; HIV-1 protein Vpu
K22892 (Vif)  vif; HIV-1 virion infectivity factor
K22202 (Vpr)  vpr; HIV-1 virus protein R
Reference
  Authors
Altfeld M, Gale M Jr
  Title
Innate immunity against HIV-1 infection.
  Journal
Nat Immunol 16:554-62 (2015)
DOI:10.1038/ni.3157
Reference
  Authors
Park SY, Waheed AA, Zhang ZR, Freed EO, Bonifacino JS
  Title
HIV-1 Vpu accessory protein induces caspase-mediated cleavage of IRF3 transcription factor.
  Journal
J Biol Chem 289:35102-10 (2014)
DOI:10.1074/jbc.M114.597062
Reference
  Authors
Doehle BP, Chang K, Rustagi A, McNevin J, McElrath MJ, Gale M Jr
  Title
Vpu mediates depletion of interferon regulatory factor 3 during HIV infection by a lysosome-dependent mechanism.
  Journal
J Virol 86:8367-74 (2012)
DOI:10.1128/JVI.00423-12
Reference
  Authors
Okumura A, Alce T, Lubyova B, Ezelle H, Strebel K, Pitha PM
  Title
HIV-1 accessory proteins VPR and Vif modulate antiviral response by targeting IRF-3 for degradation.
  Journal
Virology 373:85-97 (2008)
DOI:10.1016/j.virol.2007.10.042
LinkDB

DBGET integrated database retrieval system