KEGG   NETWORK: N00449
Entry
N00449                      Network                                

Name
HIV Tat/Nef to crosstalk between extrinsic and intrinsic apoptotic pathways
Definition
(Tat,Nef) -> CASP8 -> BID -> (BAX,BAK1) -> CYCS -- APAF1 -> CASP9 -> CASP3
  Expanded
(K19258,K22891) -> 841 -> 637 -> (581,578) -> 54205 -- 317 -> 842 -> 836
Class
nt06131 Apoptosis (viruses and bacteria)
nt06161 Human immunodeficiency virus type 1 (HIV-1)
Type
Pathogen
Pathway
hsa05170  Human immunodeficiency virus 1 infection
Disease
H01563  HIV infection
Gene
841  CASP8; caspase 8
637  BID; BH3 interacting domain death agonist
581  BAX; BCL2 associated X, apoptosis regulator
578  BAK1; BCL2 antagonist/killer 1
54205  CYCS; cytochrome c, somatic
317  APAF1; apoptotic peptidase activating factor 1
842  CASP9; caspase 9
836  CASP3; caspase 3
Perturbant
K19258 (Tat)  tat; HIV-1 protein Tat
K22891 (Nef)  nef; HIV-1 protein Nef
Reference
  Authors
Abbas W, Herbein G
  Title
T-Cell Signaling in HIV-1 Infection.
  Journal
Open Virol J 7:57-71 (2013)
DOI:10.2174/1874357920130621001
Reference
  Authors
Fevrier M, Dorgham K, Rebollo A
  Title
CD4+ T cell depletion in human immunodeficiency virus (HIV) infection: role of apoptosis.
  Journal
Viruses 3:586-612 (2011)
DOI:10.3390/v3050586
Reference
  Authors
Cummins NW, Badley AD
  Title
Mechanisms of HIV-associated lymphocyte apoptosis: 2010.
  Journal
Cell Death Dis 1:e99 (2010)
DOI:10.1038/cddis.2010.77
Reference
  Authors
Gougeon ML
  Title
Apoptosis as an HIV strategy to escape immune attack.
  Journal
Nat Rev Immunol 3:392-404 (2003)
DOI:10.1038/nri1087
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