KEGG   NETWORK: N00456
Entry
N00456                      Network                                

Name
HIV Vpr to CDC25-cell cycle G2M
Definition
Vpr -- (DCAF1+DDB1+CUL4) -> ATR -> CHEK1 -| CDC25C -> (CCNB+CDK1)
  Expanded
K22202 -- (9730+1642+(8451,8450)) -> 545 -> 1111 -| 995 -> ((891,9133,85417)+983)
Class
nt06130 Cell cycle (viruses)
nt06161 Human immunodeficiency virus type 1 (HIV-1)
Type
Pathogen
Pathway
hsa05170  Human immunodeficiency virus 1 infection
Disease
H01563  HIV infection
Gene
9730  DCAF1; DDB1 and CUL4 associated factor 1
1642  DDB1; damage specific DNA binding protein 1
8451  CUL4A; cullin 4A
8450  CUL4B; cullin 4B
545  ATR; ATR serine/threonine kinase
1111  CHEK1; checkpoint kinase 1
995  CDC25C; cell division cycle 25C
891  CCNB1; cyclin B1
9133  CCNB2; cyclin B2
85417  CCNB3; cyclin B3
983  CDK1; cyclin dependent kinase 1
Perturbant
K22202 (Vpr)  vpr; HIV-1 virus protein R
Reference
  Authors
Andersen JL, Le Rouzic E, Planelles V
  Title
HIV-1 Vpr: mechanisms of G2 arrest and apoptosis.
  Journal
Exp Mol Pathol 85:2-10 (2008)
DOI:10.1016/j.yexmp.2008.03.015
Reference
  Authors
Bregnard C, Benkirane M, Laguette N
  Title
DNA damage repair machinery and HIV escape from innate immune sensing.
  Journal
Front Microbiol 5:176 (2014)
DOI:10.3389/fmicb.2014.00176
Reference
  Authors
DeHart JL, Zimmerman ES, Ardon O, Monteiro-Filho CM, Arganaraz ER, Planelles V
  Title
HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system.
  Journal
Virol J 4:57 (2007)
DOI:10.1186/1743-422X-4-57
Reference
  Authors
Tan L, Ehrlich E, Yu XF
  Title
DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest.
  Journal
J Virol 81:10822-30 (2007)
DOI:10.1128/JVI.01380-07
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