KEGG   NETWORK: N00500
Entry
N00500                      Network                                

Name
HTLV-1 Tax to p21-cell cycle G2/M
Definition
TAX -| CHEK1
  Expanded
K21857 -| 1111
Class
nt06230 Cell cycle G1/S
nt06130 Cell cycle (viruses)
nt06160 Human T-cell leukemia virus 1 (HTLV-1)
Type
Pathogen
Pathway
hsa05166  Human T-cell leukemia virus 1 infection
Disease
H00009  Adult T-cell leukemia
Gene
1111  CHEK1; checkpoint kinase 1
Perturbant
K21857 (TAX)  tax; HTLV protein Tax-1
Reference
  Authors
Park HU, Jeong JH, Chung JH, Brady JN
  Title
Human T-cell leukemia virus type 1 Tax interacts with Chk1 and attenuates DNA-damage induced G2 arrest mediated by Chk1.
  Journal
Oncogene 23:4966-74 (2004)
DOI:10.1038/sj.onc.1207644
Reference
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
Reference
  Authors
Grassmann R, Aboud M, Jeang KT
  Title
Molecular mechanisms of cellular transformation by HTLV-1 Tax.
  Journal
Oncogene 24:5976-85 (2005)
DOI:10.1038/sj.onc.1208978
Reference
  Authors
White MK, Pagano JS, Khalili K
  Title
Viruses and human cancers: a long road of discovery of molecular paradigms.
  Journal
Clin Microbiol Rev 27:463-81 (2014)
DOI:10.1128/CMR.00124-13
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