KEGG   NETWORK: N00509
Entry
N00509                      Network                                

Name
HTLV-1 Tax to SRF-mediated transcription
Definition
TAX -> SRF => (FOS,FOSL1,EGR1,EGR2)
  Expanded
K21857 -> 6722 => (2353,8061,1958,1959)
Class
nt06160 Human T-cell leukemia virus 1 (HTLV-1)
Type
Pathogen
Pathway
hsa05166  Human T-cell leukemia virus 1 infection
Disease
H00009  Adult T-cell leukemia
Gene
6722  SRF; serum response factor
2353  FOS; Fos proto-oncogene, AP-1 transcription factor subunit
8061  FOSL1; FOS like 1, AP-1 transcription factor subunit
1958  EGR1; early growth response 1
1959  EGR2; early growth response 2
Perturbant
K21857 (TAX)  tax; HTLV protein Tax-1
Reference
PMID:1427072
  Authors
Fujii M, Tsuchiya H, Chuhjo T, Akizawa T, Seiki M
  Title
Interaction of HTLV-1 Tax1 with p67SRF causes the aberrant induction of cellular immediate early genes through CArG boxes.
  Journal
Genes Dev 6:2066-76 (1992)
DOI:10.1101/gad.6.11.2066
Reference
  Authors
Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L
  Title
The HTLV-1 Tax interactome.
  Journal
Retrovirology 5:76 (2008)
DOI:10.1186/1742-4690-5-76
Reference
  Authors
Azran I, Schavinsky-Khrapunsky Y, Aboud M
  Title
Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity.
  Journal
Retrovirology 1:20 (2004)
DOI:10.1186/1742-4690-1-20
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