KEGG   NETWORK: N00511
Entry
N00511                      Network                                

Name
HTLV-1 Tax to E47-mediated transcription
Definition
TAX -| E47 => (POLB,LCK,BAX,CDKN2C)
  Expanded
K21857 -| 6929 => (5423,3932,581,1031)
Class
nt06140 Transcription (viruses)
nt06160 Human T-cell leukemia virus 1 (HTLV-1)
Type
Pathogen
Pathway
hsa05166  Human T-cell leukemia virus 1 infection
Disease
H00009  Adult T-cell leukemia
Gene
6929  TCF3; transcription factor 3
5423  POLB; DNA polymerase beta
3932  LCK; LCK proto-oncogene, Src family tyrosine kinase
581  BAX; BCL2 associated X, apoptosis regulator
1031  CDKN2C; cyclin dependent kinase inhibitor 2C
Perturbant
K21857 (TAX)  tax; HTLV protein Tax-1
Reference
  Authors
Yoshida M
  Title
Multiple viral strategies of HTLV-1 for dysregulation of cell growth control.
  Journal
Annu Rev Immunol 19:475-96 (2001)
DOI:10.1146/annurev.immunol.19.1.475
Reference
  Authors
Suzuki T, Uchida-Toita M, Yoshida M
  Title
Tax protein of HTLV-1 inhibits CBP/p300-mediated transcription by interfering with recruitment of CBP/p300 onto DNA element of E-box or p53 binding site.
  Journal
Oncogene 18:4137-43 (1999)
DOI:10.1038/sj.onc.1202766
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