KEGG   NETWORK: N00544
Entry
N00544                      Network                                

Name
HBV HBx to CREB-mediated transcription
Definition
X -> CREBBP -- (CREB+ATF2) => (CXCL8,PCNA)
  Expanded
K21854 -> 1387 -- ((10488,1385,1386,1388,148327,468,64764,84699,90993,9586)+1386) => (3576,5111)
Class
nt06263 Hepatocellular carcinoma
nt06140 Transcription (viruses)
nt06162 Hepatitis B virus (HBV)
Type
Pathogen
Pathway
hsa05161  Hepatitis B
Disease
H00048  Hepatocellular carcinoma
Gene
1387  CREBBP; CREB binding protein
10488  CREB3; cAMP responsive element binding protein 3
1385  CREB1; cAMP responsive element binding protein 1
1386  ATF2; activating transcription factor 2
1388  ATF6B; activating transcription factor 6 beta
148327  CREB3L4; cAMP responsive element binding protein 3 like 4
468  ATF4; activating transcription factor 4
64764  CREB3L2; cAMP responsive element binding protein 3 like 2
84699  CREB3L3; cAMP responsive element binding protein 3 like 3
90993  CREB3L1; cAMP responsive element binding protein 3 like 1
9586  CREB5; cAMP responsive element binding protein 5
3576  CXCL8; C-X-C motif chemokine ligand 8
5111  PCNA; proliferating cell nuclear antigen
Perturbant
K21854 (X)  X; HBV protein X
Reference
  Authors
Benhenda S, Cougot D, Buendia MA, Neuveut C
  Title
Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis.
  Journal
Adv Cancer Res 103:75-109 (2009)
DOI:10.1016/S0065-230X(09)03004-8
Reference
  Authors
Cougot D, Wu Y, Cairo S, Caramel J, Renard CA, Levy L, Buendia MA, Neuveut C
  Title
The hepatitis B virus X protein functionally interacts with CREB-binding protein/p300 in the regulation of CREB-mediated transcription.
  Journal
J Biol Chem 282:4277-87 (2007)
DOI:10.1074/jbc.M606774200
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