KEGG   NETWORK: N00552
Entry
N00552                      Network                                

Name
HBV pol to TLR3-IRF3 signaling pathway
Definition
P -| DDX3X -- (IKBKE+TBK1)
  Expanded
K21037 -| 1654 -- (9641+29110)
Class
nt06263 Hepatocellular carcinoma
nt06121 TLR signaling (viruses and bacteria)
nt06162 Hepatitis B virus (HBV)
Type
Pathogen
Pathway
hsa05161  Hepatitis B
Disease
H00048  Hepatocellular carcinoma
Gene
1654  DDX3X; DEAD-box helicase 3 X-linked
9641  IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon
29110  TBK1; TANK binding kinase 1
Perturbant
K21037 (P)  P; Hepadnavirus DNA polymerase / reverse transcriptase / RNase H
Reference
  Authors
Yu S, Chen J, Wu M, Chen H, Kato N, Yuan Z
  Title
Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilon and DDX3.
  Journal
J Gen Virol 91:2080-90 (2010)
DOI:10.1099/vir.0.020552-0
Reference
  Authors
Revill P, Yuan Z
  Title
New insights into how HBV manipulates the innate immune response to establish acute and persistent infection.
  Journal
Antivir Ther 18:1-15 (2013)
DOI:10.3851/IMP2542
Reference
  Authors
Ariumi Y
  Title
Multiple functions of DDX3 RNA helicase in gene regulation, tumorigenesis, and viral infection.
  Journal
Front Genet 5:423 (2014)
DOI:10.3389/fgene.2014.00423
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