KEGG   NETWORK: N00866
Entry
N00866                      Network                                

Name
Yersinia YopM to Pyrin Inflammasome signaling pathway
Definition
YopM -> (PKN1,PKN2) -| (MEFV+PYCARD)
  Expanded
K23478 -> (5586,5585) -| (4210+29108)
Class
nt06139 NLR signaling (viruses and bacteria)
Type
Pathogen
Pathway
hsa05135  Yersinia infection
Disease
H00297  Plague
H00298  Yersiniosis
Gene
5586  PKN2; protein kinase N2
5585  PKN1; protein kinase N1
4210  MEFV; MEFV innate immuity regulator, pyrin
29108  PYCARD; PYD and CARD domain containing
Perturbant
K23478 (YopM)  yopM; outer membrane protein YopM
Reference
  Authors
Chung LK, Park YH, Zheng Y, Brodsky IE, Hearing P, Kastner DL, Chae JJ, Bliska JB
  Title
The Yersinia Virulence Factor YopM Hijacks Host Kinases to Inhibit Type III Effector-Triggered Activation of the Pyrin Inflammasome.
  Journal
Cell Host Microbe 20:296-306 (2016)
DOI:10.1016/j.chom.2016.07.018
Reference
  Authors
Ratner D, Orning MP, Proulx MK, Wang D, Gavrilin MA, Wewers MD, Alnemri ES, Johnson PF, Lee B, Mecsas J, Kayagaki N, Goguen JD, Lien E
  Title
The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation.
  Journal
PLoS Pathog 12:e1006035 (2016)
DOI:10.1371/journal.ppat.1006035
LinkDB

DBGET integrated database retrieval system