KEGG   NETWORK: N00869
Entry
N00869                      Network                                

Name
KISS1-KISS1R-PLCB-PKC signaling pathway
Definition
KISS1 -> KISS1R -> (GNAQ,GNA11) -> PLCB -> (Ca2+,DAG) -> PKC
  Expanded
3814 -> 84634 -> (2776,2767) -> (23236,5330,5331,5332) -> (C00076,C00165) -> (5578,5579,5582)
Class
nt06323 KISS1-GnRH-LH/FSH-E2 signaling
Type
Reference
Pathway
hsa04929  GnRH secretion
Gene
3814  KISS1; KiSS-1 metastasis suppressor
84634  KISS1R; KISS1 receptor
2776  GNAQ; G protein subunit alpha q
2767  GNA11; G protein subunit alpha 11
23236  PLCB1; phospholipase C beta 1
5330  PLCB2; phospholipase C beta 2
5331  PLCB3; phospholipase C beta 3
5332  PLCB4; phospholipase C beta 4
5578  PRKCA; protein kinase C alpha
5579  PRKCB; protein kinase C beta
5582  PRKCG; protein kinase C gamma
Metabolite
C00076  Calcium cation
C00165  Diacylglycerol
Reference
  Authors
Trevisan CM, Montagna E, de Oliveira R, Christofolini DM, Barbosa CP, Crandall KA, Bianco B
  Title
Kisspeptin/GPR54 System: What Do We Know About Its Role in Human Reproduction?
  Journal
Cell Physiol Biochem 49:1259-1276 (2018)
DOI:10.1159/000493406
Reference
  Authors
Beltramo M, Dardente H, Cayla X, Caraty A
  Title
Cellular mechanisms and integrative timing of neuroendocrine control of GnRH secretion by kisspeptin.
  Journal
Mol Cell Endocrinol 382:387-399 (2014)
DOI:10.1016/j.mce.2013.10.015
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