KEGG   NETWORK: N00907
Entry
N00907                      Network                                

Name
GH-Jak-STAT signaling pathway
Definition
GH -> GHR -> JAK2 -> STAT5 => IGF1
  Expanded
(2688,2689) -> 2690 -> 3717 -> (6776,6777) => 3479
Class
nt06324 GHRH-GH-IGF signaling
Type
Reference
Pathway
hsa04935  Growth hormone synthesis, secretion and action
Gene
2688  GH1; growth hormone 1
2689  GH2; growth hormone 2
2690  GHR; growth hormone receptor
3717  JAK2; Janus kinase 2
6776  STAT5A; signal transducer and activator of transcription 5A
6777  STAT5B; signal transducer and activator of transcription 5B
3479  IGF1; insulin like growth factor 1
Reference
  Authors
Lu M, Flanagan JU, Langley RJ, Hay MP, Perry JK
  Title
Targeting growth hormone function: strategies and therapeutic applications.
  Journal
Signal Transduct Target Ther 4:3 (2019)
DOI:10.1038/s41392-019-0036-y
Reference
PMID:8874495
  Authors
Argetsinger LS, Carter-Su C
  Title
Mechanism of signaling by growth hormone receptor.
  Journal
Physiol Rev 76:1089-107 (1996)
DOI:10.1152/physrev.1996.76.4.1089
Reference
  Authors
Dehkhoda F, Lee CMM, Medina J, Brooks AJ
  Title
The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects.
  Journal
Front Endocrinol (Lausanne) 9:35 (2018)
DOI:10.3389/fendo.2018.00035
Reference
  Authors
Carter-Su C, Rui L, Herrington J
  Title
Role of the tyrosine kinase JAK2 in signal transduction by growth hormone.
  Journal
Pediatr Nephrol 14:550-7 (2000)
DOI:10.1007/s004670000366
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