KEGG   NETWORK: N00948
Entry
N00948                      Network                                

Name
Shigella IpaH7.8 to NLRP3 Inflammasome signaling pathway
Definition
IpaH7.8 -| GLMN -| (NLRP3+PYCARD) -> CASP1 -> IL1B
  Expanded
K23834 -| 11146 -| (114548+29108) -> 834 -> 3553
Class
nt06139 NLR signaling (viruses and bacteria)
Type
Pathogen
Pathway
hsa05131  Shigellosis
Disease
H00299  Shigellosis
Gene
11146  GLMN; glomulin, FKBP associated protein
114548  NLRP3; NLR family pyrin domain containing 3
29108  PYCARD; PYD and CARD domain containing
834  CASP1; caspase 1
3553  IL1B; interleukin 1 beta
Perturbant
K23834 (IpaH7.8)  ipaH7.8; E3 ubiquitin-protein ligase IpaH7.8
Reference
  Authors
Suzuki S, Mimuro H, Kim M, Ogawa M, Ashida H, Toyotome T, Franchi L, Suzuki M, Sanada T, Suzuki T, Tsutsui H, Nunez G, Sasakawa C
  Title
Shigella IpaH7.8 E3 ubiquitin ligase targets glomulin and activates inflammasomes to demolish macrophages.
  Journal
Proc Natl Acad Sci U S A 111:E4254-63 (2014)
DOI:10.1073/pnas.1324021111
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