KEGG   NETWORK: N00950
Entry
N00950                      Network                                

Name
Shigella FimA to crosstalk between extrinsic and intrinsic apoptotic pathways
Definition
FimA -> VDAC1 -- HK -| BAX
  Expanded
K07345 -> 7416 -- (3098,3099,3101,80201) -| 581
Class
nt06131 Apoptosis (viruses and bacteria)
Type
Pathogen
Pathway
hsa05131  Shigellosis
Disease
H00299  Shigellosis
Gene
7416  VDAC1; voltage dependent anion channel 1
3098  HK1; hexokinase 1
3099  HK2; hexokinase 2
3101  HK3; hexokinase 3
80201  HKDC1; hexokinase domain containing 1
581  BAX; BCL2 associated X, apoptosis regulator
Perturbant
K07345 (FimA)  fimA; major type 1 subunit fimbrin (pilin)
Reference
  Authors
Sukumaran SK, Fu NY, Tin CB, Wan KF, Lee SS, Yu VC
  Title
A soluble form of the pilus protein FimA targets the VDAC-hexokinase complex at mitochondria to suppress host cell apoptosis.
  Journal
Mol Cell 37:768-83 (2010)
DOI:10.1016/j.molcel.2010.02.015
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