KEGG   NETWORK: N00980
Entry
N00980                      Network                                

Name
Mutation-caused aberrant Htt to REST-mediated transcriptional repression
Definition
HTT* // REST -- (SIN3A+RCOR1+(HDAC1,HDAC2)) =| BDNF
  Expanded
3064v1 // 5978 -- (25942+23186+(3065,3066)) =| 627
Class
nt06440 Transcription
nt06461 Huntington disease
Type
Variant
Pathway
hsa05016  Huntington disease
Disease
H00059  Huntington disease
Gene
3064  HTT; huntingtin
5978  REST; RE1 silencing transcription factor
25942  SIN3A; SIN3 transcription regulator family member A
23186  RCOR1; REST corepressor 1
3065  HDAC1; histone deacetylase 1
3066  HDAC2; histone deacetylase 2
627  BDNF; brain derived neurotrophic factor
Variant
3064v1 (HTT*)  HTT mutation
Reference
  Authors
Landles C, Bates GP
  Title
Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series.
  Journal
EMBO Rep 5:958-63 (2004)
DOI:10.1038/sj.embor.7400250
Reference
  Authors
Cattaneo E, Zuccato C, Tartari M
  Title
Normal huntingtin function: an alternative approach to Huntington's disease.
  Journal
Nat Rev Neurosci 6:919-30 (2005)
DOI:10.1038/nrn1806
Reference
  Authors
Moumne L, Betuing S, Caboche J
  Title
Multiple Aspects of Gene Dysregulation in Huntington's Disease.
  Journal
Front Neurol 4:127 (2013)
DOI:10.3389/fneur.2013.00127
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