KEGG   NETWORK: N00981
Entry
N00981                      Network                                

Name
Mutation-caused aberrant Htt to CREB-mediated transcription
Definition
HTT* -| (CREB+TAF4) => PPARGC1A
  Expanded
3064v1 -| ((10488,1385,1386,1388,148327,468,64764,84699,90993,9586)+6874) => 10891
Class
nt06440 Transcription
nt06461 Huntington disease
Type
Variant
Pathway
hsa05016  Huntington disease
Disease
H00059  Huntington disease
Gene
3064  HTT; huntingtin
10488  CREB3; cAMP responsive element binding protein 3
1385  CREB1; cAMP responsive element binding protein 1
1386  ATF2; activating transcription factor 2
1388  ATF6B; activating transcription factor 6 beta
148327  CREB3L4; cAMP responsive element binding protein 3 like 4
468  ATF4; activating transcription factor 4
64764  CREB3L2; cAMP responsive element binding protein 3 like 2
84699  CREB3L3; cAMP responsive element binding protein 3 like 3
90993  CREB3L1; cAMP responsive element binding protein 3 like 1
9586  CREB5; cAMP responsive element binding protein 5
6874  TAF4; TATA-box binding protein associated factor 4
10891  PPARGC1A; PPARG coactivator 1 alpha
Variant
3064v1 (HTT*)  HTT mutation
Reference
  Authors
Bossy-Wetzel E, Petrilli A, Knott AB
  Title
Mutant huntingtin and mitochondrial dysfunction.
  Journal
Trends Neurosci 31:609-16 (2008)
DOI:10.1016/j.tins.2008.09.004
Reference
  Authors
McGill JK, Beal MF
  Title
PGC-1alpha, a new therapeutic target in Huntington's disease?
  Journal
Cell 127:465-8 (2006)
DOI:10.1016/j.cell.2006.10.023
Reference
  Authors
Paul BD, Snyder SH
  Title
Impaired Redox Signaling in Huntington's Disease: Therapeutic Implications.
  Journal
Front Mol Neurosci 12:68 (2019)
DOI:10.3389/fnmol.2019.00068
Reference
  Authors
Intihar TA, Martinez EA, Gomez-Pastor R
  Title
Mitochondrial Dysfunction in Huntington's Disease; Interplay Between HSF1, p53 and PGC-1alpha Transcription Factors.
  Journal
Front Cell Neurosci 13:103 (2019)
DOI:10.3389/fncel.2019.00103
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