KEGG   NETWORK: N00982
Entry
N00982                      Network                                

Name
Mutation-caused aberrant Htt to p53-mediated transcription
Definition
HTT* -> TP53 => (BAX,BBC3)
  Expanded
3064v1 -> 7157 => (581,27113)
Class
nt06440 Transcription
nt06461 Huntington disease
Type
Variant
Pathway
hsa05016  Huntington disease
Disease
H00059  Huntington disease
Gene
3064  HTT; huntingtin
7157  TP53; tumor protein p53
581  BAX; BCL2 associated X, apoptosis regulator
27113  BBC3; BCL2 binding component 3
Variant
3064v1 (HTT*)  HTT mutation
Reference
  Authors
Bae BI, Xu H, Igarashi S, Fujimuro M, Agrawal N, Taya Y, Hayward SD, Moran TH, Montell C, Ross CA, Snyder SH, Sawa A
  Title
p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease.
  Journal
Neuron 47:29-41 (2005)
DOI:10.1016/j.neuron.2005.06.005
Reference
  Authors
La Spada AR, Morrison RS
  Title
The power of the dark side: Huntington's disease protein and p53 form a deadly alliance.
  Journal
Neuron 47:1-3 (2005)
DOI:10.1016/j.neuron.2005.06.023
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