KEGG   NETWORK: N00986
Entry
N00986                      Network                                

Name
Mutation-caused aberrant Htt to VGCC-Ca2+ -apoptotic pathway
Definition
HTT* -| STX1A -| VGCC(N-type) -> Ca2+
  Expanded
3064v1 -| 6804 -| 774 -> C00076
Class
nt06410 Calcium signaling
nt06461 Huntington disease
Type
Variant
Pathway
hsa05016  Huntington disease
Disease
H00059  Huntington disease
Gene
3064  HTT; huntingtin
6804  STX1A; syntaxin 1A
774  CACNA1B; calcium voltage-gated channel subunit alpha1 B
Variant
3064v1 (HTT*)  HTT mutation
Metabolite
C00076  Calcium cation
Reference
  Authors
Swayne LA, Chen L, Hameed S, Barr W, Charlesworth E, Colicos MA, Zamponi GW, Braun JE
  Title
Crosstalk between huntingtin and syntaxin 1A regulates N-type calcium channels.
  Journal
Mol Cell Neurosci 30:339-51 (2005)
DOI:10.1016/j.mcn.2005.07.016
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