KEGG   NETWORK: N00993
Entry
N00993                      Network                                

Name
Mutation-caused aberrant Htt to autophagy-vesicle nucleation
Definition
HTT* -| (BECN1+PIK3C3+ATG14+PIK3R4+AMBRA1) -> PI3P
  Expanded
3064v1 -| (8678+5289+22863+30849+55626) -> C04549
Class
nt06413 Autophagy
nt06461 Huntington disease
Type
Variant
Pathway
hsa05016  Huntington disease
Disease
H00059  Huntington disease
Gene
3064  HTT; huntingtin
8678  BECN1; beclin 1
5289  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3
22863  ATG14; autophagy related 14
30849  PIK3R4; phosphoinositide-3-kinase regulatory subunit 4
55626  AMBRA1; autophagy and beclin 1 regulator 1
Variant
3064v1 (HTT*)  HTT mutation
Metabolite
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
  Authors
Vidal RL, Matus S, Bargsted L, Hetz C
  Title
Targeting autophagy in neurodegenerative diseases.
  Journal
Trends Pharmacol Sci 35:583-91 (2014)
DOI:10.1016/j.tips.2014.09.002
Reference
  Authors
Shibata M, Lu T, Furuya T, Degterev A, Mizushima N, Yoshimori T, MacDonald M, Yankner B, Yuan J
  Title
Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1.
  Journal
J Biol Chem 281:14474-85 (2006)
DOI:10.1074/jbc.M600364200
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