Entry |
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Name |
Mutation-caused aberrant Abeta to AGE-RAGE signaling pathway
|
Definition |
APP* -> Abeta -> AGER -> RAS -> RAF -> MEK -> ERK -> NFKB => (TNF,IL6,NOS2) |
Expanded |
351v1 -> (C16515,C16514) -> 177 -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) -> (4790+5970) => (7124,3569,4843) |
Class |
|
Type |
Variant
|
Pathway |
|
Disease |
|
Gene |
351 | APP; amyloid beta precursor protein |
177 | AGER; advanced glycosylation end-product specific receptor |
3265 | HRAS; HRas proto-oncogene, GTPase |
3845 | KRAS; KRAS proto-oncogene, GTPase |
4893 | NRAS; NRAS proto-oncogene, GTPase |
369 | ARAF; A-Raf proto-oncogene, serine/threonine kinase |
673 | BRAF; B-Raf proto-oncogene, serine/threonine kinase |
5894 | RAF1; Raf-1 proto-oncogene, serine/threonine kinase |
5604 | MAP2K1; mitogen-activated protein kinase kinase 1 |
5605 | MAP2K2; mitogen-activated protein kinase kinase 2 |
5594 | MAPK1; mitogen-activated protein kinase 1 |
5595 | MAPK3; mitogen-activated protein kinase 3 |
4790 | NFKB1; nuclear factor kappa B subunit 1 |
5970 | RELA; RELA proto-oncogene, NF-kB subunit |
7124 | TNF; tumor necrosis factor |
4843 | NOS2; nitric oxide synthase 2 |
|
Variant |
351v1 (APP*) APP mutation
|
Metabolite |
C16515 | Beta-amyloid protein 42 |
C16514 | Beta-amyloid protein 40 |
|
Reference |
|
Authors |
Small DH, Mok SS, Bornstein JC |
Title |
Alzheimer's disease and Abeta toxicity: from top to bottom. |
Journal |
|
Reference |
|
Authors |
Srikanth V, Maczurek A, Phan T, Steele M, Westcott B, Juskiw D, Munch G |
Title |
Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease. |
Journal |
|
Reference |
|
Authors |
Origlia N, Arancio O, Domenici L, Yan SS |
Title |
MAPK, beta-amyloid and synaptic dysfunction: the role of RAGE. |
Journal |
|
Reference |
|
Authors |
Origlia N, Capsoni S, Cattaneo A, Fang F, Arancio O, Yan SD, Domenici L |
Title |
Abeta-dependent Inhibition of LTP in different intracortical circuits of the visual cortex: the role of RAGE. |
Journal |
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LinkDB |
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