KEGG   NETWORK: N01009
Entry
N01009                      Network                                

Name
PERK-ATF4 signaling pathway
Definition
EIF2AK3 -> EIF2S1 -> ATF4 => DDIT3
  Expanded
9451 -> 1965 -> 468 => 1649
Class
nt06412 Unfolded protein response (UPR) signaling
nt06460 Alzheimer disease
nt06463 Parkinson disease
nt06464 Amyotrophic lateral sclerosis
nt06465 Prion disease
Type
Reference
Pathway
hsa04141  Protein processing in endoplasmic reticulum
Gene
9451  EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3
1965  EIF2S1; eukaryotic translation initiation factor 2 subunit alpha
468  ATF4; activating transcription factor 4
1649  DDIT3; DNA damage inducible transcript 3
Reference
  Authors
Walter P, Ron D
  Title
The unfolded protein response: from stress pathway to homeostatic regulation.
  Journal
Science 334:1081-6 (2011)
DOI:10.1126/science.1209038
Reference
  Authors
Kim I, Xu W, Reed JC
  Title
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities.
  Journal
Nat Rev Drug Discov 7:1013-30 (2008)
DOI:10.1038/nrd2755
Reference
  Authors
Deldicque L
  Title
Endoplasmic reticulum stress in human skeletal muscle: any contribution to sarcopenia?
  Journal
Front Physiol 4:236 (2013)
DOI:10.3389/fphys.2013.00236
Reference
  Authors
Basseri S, Austin RC
  Title
Endoplasmic reticulum stress and lipid metabolism: mechanisms and therapeutic potential.
  Journal
Biochem Res Int 2012:841362 (2012)
DOI:10.1155/2012/841362
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