KEGG   NETWORK: N01011
Entry
N01011                      Network                                

Name
IRE1a-XBP1 signaling pathway
Definition
ERN1 -> XBP1 => DDIT3
  Expanded
2081 -> 7494 => 1649
Class
nt06412 Unfolded protein response (UPR) signaling
nt06460 Alzheimer disease
nt06463 Parkinson disease
nt06464 Amyotrophic lateral sclerosis
Type
Reference
Pathway
hsa04141  Protein processing in endoplasmic reticulum
Gene
2081  ERN1; endoplasmic reticulum to nucleus signaling 1
7494  XBP1; X-box binding protein 1
1649  DDIT3; DNA damage inducible transcript 3
Reference
  Authors
Walter P, Ron D
  Title
The unfolded protein response: from stress pathway to homeostatic regulation.
  Journal
Science 334:1081-6 (2011)
DOI:10.1126/science.1209038
Reference
  Authors
Kim I, Xu W, Reed JC
  Title
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities.
  Journal
Nat Rev Drug Discov 7:1013-30 (2008)
DOI:10.1038/nrd2755
Reference
  Authors
Deldicque L
  Title
Endoplasmic reticulum stress in human skeletal muscle: any contribution to sarcopenia?
  Journal
Front Physiol 4:236 (2013)
DOI:10.3389/fphys.2013.00236
Reference
  Authors
Basseri S, Austin RC
  Title
Endoplasmic reticulum stress and lipid metabolism: mechanisms and therapeutic potential.
  Journal
Biochem Res Int 2012:841362 (2012)
DOI:10.1155/2012/841362
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