KEGG   NETWORK: N01013
Entry
N01013                      Network                                

Name
IRE1a-JNK signaling pathway
Definition
ERN1 -> TRAF2 -> MAP3K5 -> MAP2K7 -> JNK
  Expanded
2081 -> 7186 -> 4217 -> 5609 -> (5599,5601,5602)
Class
nt06412 Unfolded protein response (UPR) signaling
nt06460 Alzheimer disease
Type
Reference
Pathway
hsa04141  Protein processing in endoplasmic reticulum
Gene
2081  ERN1; endoplasmic reticulum to nucleus signaling 1
7186  TRAF2; TNF receptor associated factor 2
4217  MAP3K5; mitogen-activated protein kinase kinase kinase 5
5609  MAP2K7; mitogen-activated protein kinase kinase 7
5599  MAPK8; mitogen-activated protein kinase 8
5601  MAPK9; mitogen-activated protein kinase 9
5602  MAPK10; mitogen-activated protein kinase 10
Reference
  Authors
Deldicque L
  Title
Endoplasmic reticulum stress in human skeletal muscle: any contribution to sarcopenia?
  Journal
Front Physiol 4:236 (2013)
DOI:10.3389/fphys.2013.00236
Reference
  Authors
Kim I, Xu W, Reed JC
  Title
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities.
  Journal
Nat Rev Drug Discov 7:1013-30 (2008)
DOI:10.1038/nrd2755
Reference
  Authors
Bell MC, Meier SE, Ingram AL, Abisambra JF
  Title
PERK-opathies: An Endoplasmic Reticulum Stress Mechanism Underlying Neurodegeneration.
  Journal
Curr Alzheimer Res 13:150-63 (2016)
DOI:10.2174/1567205013666151218145431
Reference
  Authors
Junjappa RP, Patil P, Bhattarai KR, Kim HR, Chae HJ
  Title
IRE1alpha Implications in Endoplasmic Reticulum Stress-Mediated Development and Pathogenesis of Autoimmune Diseases.
  Journal
Front Immunol 9:1289 (2018)
DOI:10.3389/fimmu.2018.01289
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