KEGG   NETWORK: N01067
Entry
N01067                      Network                                

Name
Shigella IpgD to ARNO-ARF-ACTB_G signaling pathway
Definition
IpgD -> PI(5)P -> PI3K -> PIP3 -> ARNO -> ARF6 -> ARF1 -> (WASF+ABI1+HSPC300+CYFIP+NCKAP1) -> ARP2/3 -> (ACTB,ACTG1)
  Expanded
K13085 -> C11557 -> (5290,5291,5293) -> C05981 -> (27128,9265,9266,9267) -> 382 -> 375 -> ((10163,10810,8936)+10006+55845+(23191,26999)+(10787,3071)) -> (10097+10096+10552+10095+10109+10094+10093+10092+81873) -> (60,71)
Class
nt06135 Cytoskeletal regulation (viruses)
Type
Pathogen
Pathway
hsa05131  Shigellosis
Disease
H00299  Shigellosis
Gene
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
27128  CYTH4; cytohesin 4
9265  CYTH3; cytohesin 3
9266  CYTH2; cytohesin 2
9267  CYTH1; cytohesin 1
382  ARF6; ADP ribosylation factor 6
375  ARF1; ADP ribosylation factor 1
10163  WASF2; WASP family member 2
10810  WASF3; WASP family member 3
8936  WASF1; WASP family member 1
10006  ABI1; abl interactor 1
55845  BRK1; BRICK1 subunit of SCAR/WAVE actin nucleating complex
23191  CYFIP1; cytoplasmic FMR1 interacting protein 1
26999  CYFIP2; cytoplasmic FMR1 interacting protein 2
10787  NCKAP1; NCK associated protein 1
3071  NCKAP1L; NCK associated protein 1 like
10097  ACTR2; actin related protein 2
10096  ACTR3; actin related protein 3
10552  ARPC1A; actin related protein 2/3 complex subunit 1A
10095  ARPC1B; actin related protein 2/3 complex subunit 1B
10109  ARPC2; actin related protein 2/3 complex subunit 2
10094  ARPC3; actin related protein 2/3 complex subunit 3
10093  ARPC4; actin related protein 2/3 complex subunit 4
10092  ARPC5; actin related protein 2/3 complex subunit 5
81873  ARPC5L; actin related protein 2/3 complex subunit 5 like
60  ACTB; actin beta
71  ACTG1; actin gamma 1
Perturbant
K13085 (IpgD)  ipgD; phosphatidylinositol-4,5-bisphosphate 4-phosphatase
Metabolite
C11557  1-Phosphatidyl-1D-myo-inositol 5-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Garza-Mayers AC, Miller KA, Russo BC, Nagda DV, Goldberg MB
  Title
Shigella flexneri regulation of ARF6 activation during bacterial entry via an IpgD-mediated positive feedback loop.
  Journal
mBio 6:e02584 (2015)
DOI:10.1128/mBio.02584-14
Reference
  Authors
Van Acker T, Tavernier J, Peelman F
  Title
The Small GTPase Arf6: An Overview of Its Mechanisms of Action and of Its Role in Host(-)Pathogen Interactions and Innate Immunity.
  Journal
Int J Mol Sci 20:E2209 (2019)
DOI:10.3390/ijms20092209
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