KEGG   NETWORK: N01069
Entry
N01069                      Network                                

Name
Shigella IpgB1 to ITGA/B-FAK-RAC signaling pathway
Definition
IpgB1 -> RAC1
  Expanded
K13742 -> 5879
Class
nt06135 Cytoskeletal regulation (viruses)
Type
Pathogen
Pathway
hsa05131  Shigellosis
Disease
H00299  Shigellosis
Gene
5879  RAC1; Rac family small GTPase 1
Perturbant
K13742 (IpgB1)  ipgB1; protein IpgB1
Reference
  Authors
Ohya K, Handa Y, Ogawa M, Suzuki M, Sasakawa C
  Title
IpgB1 is a novel Shigella effector protein involved in bacterial invasion of host cells. Its activity to promote membrane ruffling via Rac1 and Cdc42 activation.
  Journal
J Biol Chem 280:24022-34 (2005)
DOI:10.1074/jbc.M502509200
Reference
  Authors
Huang Z, Sutton SE, Wallenfang AJ, Orchard RC, Wu X, Feng Y, Chai J, Alto NM
  Title
Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics.
  Journal
Nat Struct Mol Biol 16:853-60 (2009)
DOI:10.1038/nsmb.1647
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