KEGG   NETWORK: N01073
Entry
N01073                      Network                                

Name
Shigella IpgB2 to ITGA/B-RhoGEF-RhoA signaling pathway
Definition
IpgB2 -> RHOA
  Expanded
K13743 -> 387
Class
nt06135 Cytoskeletal regulation (viruses)
Type
Pathogen
Pathway
hsa05131  Shigellosis
Disease
H00299  Shigellosis
Gene
387  RHOA; ras homolog family member A
Perturbant
K13743 (IpgB2)  ipgB2; protein IpgB2
Reference
  Authors
Huang Z, Sutton SE, Wallenfang AJ, Orchard RC, Wu X, Feng Y, Chai J, Alto NM
  Title
Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics.
  Journal
Nat Struct Mol Biol 16:853-60 (2009)
DOI:10.1038/nsmb.1647
Reference
  Authors
Klink BU, Barden S, Heidler TV, Borchers C, Ladwein M, Stradal TE, Rottner K, Heinz DW
  Title
Structure of Shigella IpgB2 in complex with human RhoA: implications for the mechanism of bacterial guanine nucleotide exchange factor mimicry.
  Journal
J Biol Chem 285:17197-208 (2010)
DOI:10.1074/jbc.M110.107953
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