KEGG   NETWORK: N01074
Entry
N01074                      Network                                

Name
Shigella IpaA to ITGA/B-RhoGEF-RhoA signaling pathway
Definition
IpaA -> RHOA -> ROCK1/2 -> MLC
  Expanded
K13284 -> 387 -> (6093,9475) -> (103910,10398,10627,29895,4633,4636,58498,93408)
Class
nt06135 Cytoskeletal regulation (viruses)
Type
Pathogen
Pathway
hsa05131  Shigellosis
Disease
H00299  Shigellosis
Gene
387  RHOA; ras homolog family member A
6093  ROCK1; Rho associated coiled-coil containing protein kinase 1
9475  ROCK2; Rho associated coiled-coil containing protein kinase 2
103910  MYL12B; myosin light chain 12B
10398  MYL9; myosin light chain 9
10627  MYL12A; myosin light chain 12A
29895  MYLPF; myosin light chain, phosphorylatable, fast skeletal muscle
4633  MYL2; myosin light chain 2
4636  MYL5; myosin light chain 5
58498  MYL7; myosin light chain 7
93408  MYL10; myosin light chain 10
Perturbant
K13284 (IpaA)  sipA; invasin A
Reference
  Authors
Demali KA, Jue AL, Burridge K
  Title
IpaA targets beta1 integrins and rho to promote actin cytoskeleton rearrangements necessary for Shigella entry.
  Journal
J Biol Chem 281:39534-41 (2006)
DOI:10.1074/jbc.M605939200
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