KEGG   NETWORK: N01079
Entry
N01079                      Network                                

Name
Shigella IpaC to Actin signaling pathway
Definition
IpaC -> SRC -> CTTN -> ARP2/3 -> (ACTB,ACTG1)
  Expanded
K13286 -> 6714 -> 2017 -> (10097+10096+10552+10095+10109+10094+10093+10092+81873) -> (60,71)
Class
nt06135 Cytoskeletal regulation (viruses)
Type
Pathogen
Pathway
hsa05131  Shigellosis
Disease
H00299  Shigellosis
Gene
6714  SRC; SRC proto-oncogene, non-receptor tyrosine kinase
2017  CTTN; cortactin
10097  ACTR2; actin related protein 2
10096  ACTR3; actin related protein 3
10552  ARPC1A; actin related protein 2/3 complex subunit 1A
10095  ARPC1B; actin related protein 2/3 complex subunit 1B
10109  ARPC2; actin related protein 2/3 complex subunit 2
10094  ARPC3; actin related protein 2/3 complex subunit 3
10093  ARPC4; actin related protein 2/3 complex subunit 4
10092  ARPC5; actin related protein 2/3 complex subunit 5
81873  ARPC5L; actin related protein 2/3 complex subunit 5 like
60  ACTB; actin beta
71  ACTG1; actin gamma 1
Perturbant
K13286 (IpaC)  sipC; invasin C
Reference
  Authors
Mounier J, Popoff MR, Enninga J, Frame MC, Sansonetti PJ, Van Nhieu GT
  Title
The IpaC carboxyterminal effector domain mediates Src-dependent actin polymerization during Shigella invasion of epithelial cells.
  Journal
PLoS Pathog 5:e1000271 (2009)
DOI:10.1371/journal.ppat.1000271
Reference
  Authors
Bougneres L, Girardin SE, Weed SA, Karginov AV, Olivo-Marin JC, Parsons JT, Sansonetti PJ, Van Nhieu GT
  Title
Cortactin and Crk cooperate to trigger actin polymerization during Shigella invasion of epithelial cells.
  Journal
J Cell Biol 166:225-35 (2004)
DOI:10.1083/jcb.200402073
Reference
  Authors
Selbach M, Backert S
  Title
Cortactin: an Achilles' heel of the actin cytoskeleton targeted by pathogens.
  Journal
Trends Microbiol 13:181-9 (2005)
DOI:10.1016/j.tim.2005.02.007
LinkDB

DBGET integrated database retrieval system