KEGG   NETWORK: N01080
Entry
N01080                      Network                                

Name
ITGA/B-TALIN/VINCULIN signaling pathway
Definition
FN1 -> (ITGA+ITGB) -> (PTK2+PXN+ILK) -> (TLN+ACTN1/4+VCN) -> (ACTB,ACTG1)
  Expanded
2335 -> ((3672,3673,3674,3675,3676,3678,3679,8516,3680,8515,22801,3685)+(3688,3690,3691,3693,3694,3695,3696)) -> (5747+5829+3611) -> ((7094,83660)+(87,81)+7414) -> (60,71)
Class
nt06135 Cytoskeletal regulation (viruses and bacteria)
Type
Reference
Pathway
hsa04510  Focal adhesion
Gene
2335  FN1; fibronectin 1
3672  ITGA1; integrin subunit alpha 1
3673  ITGA2; integrin subunit alpha 2
3674  ITGA2B; integrin subunit alpha 2b
3675  ITGA3; integrin subunit alpha 3
3676  ITGA4; integrin subunit alpha 4
3678  ITGA5; integrin subunit alpha 5
3679  ITGA7; integrin subunit alpha 7
8516  ITGA8; integrin subunit alpha 8
3680  ITGA9; integrin subunit alpha 9
8515  ITGA10; integrin subunit alpha 10
22801  ITGA11; integrin subunit alpha 11
3685  ITGAV; integrin subunit alpha V
3688  ITGB1; integrin subunit beta 1
3690  ITGB3; integrin subunit beta 3
3691  ITGB4; integrin subunit beta 4
3693  ITGB5; integrin subunit beta 5
3694  ITGB6; integrin subunit beta 6
3695  ITGB7; integrin subunit beta 7
3696  ITGB8; integrin subunit beta 8
5747  PTK2; protein tyrosine kinase 2
5829  PXN; paxillin
3611  ILK; integrin linked kinase
7094  TLN1; talin 1
83660  TLN2; talin 2
87  ACTN1; actinin alpha 1
81  ACTN4; actinin alpha 4
7414  VCL; vinculin
60  ACTB; actin beta
71  ACTG1; actin gamma 1
Reference
  Authors
Bachir AI, Horwitz AR, Nelson WJ, Bianchini JM
  Title
Actin-Based Adhesion Modules Mediate Cell Interactions with the Extracellular Matrix and Neighboring Cells.
  Journal
Cold Spring Harb Perspect Biol 9:a023234 (2017)
DOI:10.1101/cshperspect.a023234
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