KEGG   NETWORK: N01082
Entry
N01082                      Network                                

Name
Shigella IpaA to ITGA/B-TALIN/VINCULIN signaling pathway
Definition
IpaA -> (ACTN1/4+VCN)
  Expanded
K13284 -> ((87,81)+7414)
Class
nt06135 Cytoskeletal regulation (viruses)
Type
Pathogen
Pathway
hsa05131  Shigellosis
Disease
H00299  Shigellosis
Gene
87  ACTN1; actinin alpha 1
81  ACTN4; actinin alpha 4
7414  VCL; vinculin
Perturbant
K13284 (IpaA)  sipA; invasin A
Reference
PMID:9184218
  Authors
Tran Van Nhieu G, Ben-Ze'ev A, Sansonetti PJ
  Title
Modulation of bacterial entry into epithelial cells by association between vinculin and the Shigella IpaA invasin.
  Journal
EMBO J 16:2717-29 (1997)
DOI:10.1093/emboj/16.10.2717
Reference
  Authors
Hamiaux C, van Eerde A, Parsot C, Broos J, Dijkstra BW
  Title
Structural mimicry for vinculin activation by IpaA, a virulence factor of Shigella flexneri.
  Journal
EMBO Rep 7:794-9 (2006)
DOI:10.1038/sj.embor.7400753
Reference
  Authors
Izard T, Tran Van Nhieu G, Bois PR
  Title
Shigella applies molecular mimicry to subvert vinculin and invade host cells.
  Journal
J Cell Biol 175:465-75 (2006)
DOI:10.1083/jcb.200605091
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