KEGG   NETWORK: N01083
Entry
N01083                      Network                                

Name
Shigella OspE to ITGA/B-TALIN/VINCULIN signaling pathway
Definition
OspE -| (PTK2+PXN+ILK)
  Expanded
K13793 -| (5747+5829+3611)
Class
nt06135 Cytoskeletal regulation (viruses)
Type
Pathogen
Pathway
hsa05131  Shigellosis
Disease
H00299  Shigellosis
Gene
5747  PTK2; protein tyrosine kinase 2
5829  PXN; paxillin
3611  ILK; integrin linked kinase
Perturbant
K13793 (OspE)  ospE; secreted effector OspE
Reference
  Authors
Kim M, Ogawa M, Fujita Y, Yoshikawa Y, Nagai T, Koyama T, Nagai S, Lange A, Fassler R, Sasakawa C
  Title
Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment.
  Journal
Nature 459:578-82 (2009)
DOI:10.1038/nature07952
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