KEGG   NETWORK: N01088
Entry
N01088                      Network                                

Name
Escherichia EspH to LPA-GNA12/13-RhoA signaling pathway
Definition
EspH -| (ARHGEF12,ARHGEF1)
  Expanded
K12788 -| (23365,9138)
Class
nt06135 Cytoskeletal regulation (viruses)
Type
Pathogen
Pathway
hsa05130  Pathogenic Escherichia coli infection
Disease
H00277  Enterohemorrhagic Escherichia coli (EHEC) infection
H00278  Enteropathogenic Escherichia coli (EPEC) infection
Gene
23365  ARHGEF12; Rho guanine nucleotide exchange factor 12
9138  ARHGEF1; Rho guanine nucleotide exchange factor 1
Perturbant
K12788 (EspH)  espH; LEE-encoded effector EspH
Reference
  Authors
Dong N, Liu L, Shao F
  Title
A bacterial effector targets host DH-PH domain RhoGEFs and antagonizes macrophage phagocytosis.
  Journal
EMBO J 29:1363-76 (2010)
DOI:10.1038/emboj.2010.33
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