KEGG   NETWORK: N01089
Entry
N01089                      Network                                

Name
Escherichia EspM to LPA-GNA12/13-Rho signaling pathway
Definition
EspM -> RHOA -> ROCK1/2
  Expanded
K23653 -> 387 -> (6093,9475)
Class
nt06135 Cytoskeletal regulation (viruses)
Type
Pathogen
Pathway
hsa05130  Pathogenic Escherichia coli infection
Disease
H00277  Enterohemorrhagic Escherichia coli (EHEC) infection
H00278  Enteropathogenic Escherichia coli (EPEC) infection
Gene
387  RHOA; ras homolog family member A
6093  ROCK1; Rho associated coiled-coil containing protein kinase 1
9475  ROCK2; Rho associated coiled-coil containing protein kinase 2
Perturbant
K23653 (EspM)  espM; T3SS effector EspM
Reference
  Authors
Simovitch M, Sason H, Cohen S, Zahavi EE, Melamed-Book N, Weiss A, Aroeti B, Rosenshine I
  Title
EspM inhibits pedestal formation by enterohaemorrhagic Escherichia coli and enteropathogenic E. coli and disrupts the architecture of a polarized epithelial  monolayer.
  Journal
Cell Microbiol 12:489-505 (2010)
DOI:10.1111/j.1462-5822.2009.01410.x
Reference
  Authors
Arbeloa A, Garnett J, Lillington J, Bulgin RR, Berger CN, Lea SM, Matthews S, Frankel G
  Title
EspM2 is a RhoA guanine nucleotide exchange factor.
  Journal
Cell Microbiol 12:654-64 (2010)
DOI:10.1111/j.1462-5822.2009.01423.x
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