KEGG   NETWORK: N01090
Entry
N01090                      Network                                

Name
IGG-FCGR-RAC signaling pathway
Definition
IGG -> FCGR -> CRK -> DOCK1 -> RAC
  Expanded
102723407 -> (2209,2212,2214,2215) -> 1398 -> 1793 -> (5879,5880,5881)
Class
nt06135 Cytoskeletal regulation (viruses and bacteria)
Type
Reference
Pathway
hsa04666  Fc gamma R-mediated phagocytosis
Gene
102723407  IGH; immunoglobulin heavy variable 4-38-2-like
2209  FCGR1A; Fc fragment of IgG receptor Ia
2212  FCGR2A; Fc fragment of IgG receptor IIa
2214  FCGR3A; Fc fragment of IgG receptor IIIa
2215  FCGR3B; Fc fragment of IgG receptor IIIb
1398  CRK; CRK proto-oncogene, adaptor protein
1793  DOCK1; dedicator of cytokinesis 1
5879  RAC1; Rac family small GTPase 1
5880  RAC2; Rac family small GTPase 2
5881  RAC3; Rac family small GTPase 3
Reference
  Authors
May RC, Machesky LM
  Title
Phagocytosis and the actin cytoskeleton.
  Journal
J Cell Sci 114:1061-77 (2001)
Reference
  Authors
Lee WL, Cosio G, Ireton K, Grinstein S
  Title
Role of CrkII in Fcgamma receptor-mediated phagocytosis.
  Journal
J Biol Chem 282:11135-43 (2007)
DOI:10.1074/jbc.M700823200
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