KEGG   NETWORK: N01093
Entry
N01093                      Network                                

Name
Escherichia EspJ/Tir to Actin signaling pathway
Definition
EspJ -| (FYN,ABL) -> Tir -> NCK
  Expanded
K23648 -| (2534,25) -> K12784 -> (4690,8440)
Class
nt06135 Cytoskeletal regulation (viruses)
Type
Pathogen
Pathway
hsa05130  Pathogenic Escherichia coli infection
Disease
H00277  Enterohemorrhagic Escherichia coli (EHEC) infection
H00278  Enteropathogenic Escherichia coli (EPEC) infection
Gene
2534  FYN; FYN proto-oncogene, Src family tyrosine kinase
25  ABL1; ABL proto-oncogene 1, non-receptor tyrosine kinase
4690  NCK1; NCK adaptor protein 1
8440  NCK2; NCK adaptor protein 2
Perturbant
K23648 (EspJ)  espJ; T3SS secreted effector ADP-ribosyltransferase EspJ
K12784 (Tir)  tir; translocated intimin receptor
Reference
  Authors
Young JC, Clements A, Lang AE, Garnett JA, Munera D, Arbeloa A, Pearson J, Hartland EL, Matthews SJ, Mousnier A, Barry DJ, Way M, Schlosser A, Aktories K, Frankel G
  Title
The Escherichia coli effector EspJ blocks Src kinase activity via amidation and ADP ribosylation.
  Journal
Nat Commun 5:5887 (2014)
DOI:10.1038/ncomms6887
Reference
  Authors
Lai Y, Rosenshine I, Leong JM, Frankel G
  Title
Intimate host attachment: enteropathogenic and enterohaemorrhagic Escherichia coli.
  Journal
Cell Microbiol 15:1796-808 (2013)
DOI:10.1111/cmi.12179
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