KEGG   NETWORK: N01108
Entry
N01108                      Network                                

Name
Yersinia YopH to TCR-NFAT signaling pathway
Definition
YopH -| (SLP76,LAT,VAV)
  Expanded
K23474 -| (3937,27040,(7409,7410,10451))
Class
nt06120 Calcium signaling (viruses)
Type
Pathogen
Pathway
hsa05135  Yersinia infection
Disease
H00297  Plague
H00298  Yersiniosis
Gene
3937  LCP2; lymphocyte cytosolic protein 2
27040  LAT; linker for activation of T cells
7409  VAV1; vav guanine nucleotide exchange factor 1
7410  VAV2; vav guanine nucleotide exchange factor 2
10451  VAV3; vav guanine nucleotide exchange factor 3
Perturbant
K23474 (YopH)  yopH; tyrosine-protein phosphatase YopH
Reference
  Authors
Gerke C, Falkow S, Chien YH
  Title
The adaptor molecules LAT and SLP-76 are specifically targeted by Yersinia to inhibit T cell activation.
  Journal
J Exp Med 201:361-71 (2005)
DOI:10.1084/jem.20041120
Reference
  Authors
Rolan HG, Durand EA, Mecsas J
  Title
Identifying Yersinia YopH-targeted signal transduction pathways that impair neutrophil responses during in vivo murine infection.
  Journal
Cell Host Microbe 14:306-17 (2013)
DOI:10.1016/j.chom.2013.08.013
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