KEGG   NETWORK: N01119
Entry
N01119                      Network                                

Name
RAC/CDC42-PAK-ERK signaling pathway
Definition
(RAC1,CDC42) -> PAK1 -> RAF -> MEK -> ERK
  Expanded
(5879,998) -> 5058 -> (369,673,5894) -> (5604,5605) -> (5594,5595)
Class
nt06110 MAPK signaling (viruses and bacteria)
Type
Reference
Pathway
hsa04010  MAPK signaling pathway
Gene
5879  RAC1; Rac family small GTPase 1
998  CDC42; cell division cycle 42
5058  PAK1; p21 (RAC1) activated kinase 1
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
Reference
  Authors
Shaul YD, Seger R
  Title
The MEK/ERK cascade: from signaling specificity to diverse functions.
  Journal
Biochim Biophys Acta 1773:1213-26 (2007)
DOI:10.1016/j.bbamcr.2006.10.005
Reference
PMID:9351825
  Authors
Frost JA, Steen H, Shapiro P, Lewis T, Ahn N, Shaw PE, Cobb MH
  Title
Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins.
  Journal
EMBO J 16:6426-38 (1997)
DOI:10.1093/emboj/16.21.6426
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