KEGG   NETWORK: N01142
Entry
N01142                      Network                                

Name
C9orf72-mediated autophagy initiation
Definition
RAB1A -> (C9orf72+WDR41+SMCR8) -> (ULK1+RB1CC1+ATG101+ATG13)
  Expanded
5861 -> (203228+55255+140775) -> (8408+9821+60673+9776)
Class
nt06413 Autophagy
nt06464 Amyotrophic lateral sclerosis
Type
Reference
Pathway
hsa04140  Autophagy - animal
Gene
5861  RAB1A; RAB1A, member RAS oncogene family
203228  C9orf72; C9orf72-SMCR8 complex subunit
55255  WDR41; WD repeat domain 41
140775  SMCR8; SMCR8-C9orf72 complex subunit
8408  ULK1; unc-51 like autophagy activating kinase 1
9821  RB1CC1; RB1 inducible coiled-coil 1
60673  ATG101; autophagy related 101
9776  ATG13; autophagy related 13
Reference
  Authors
Webster CP, Smith EF, Grierson AJ, De Vos KJ
  Title
C9orf72 plays a central role in Rab GTPase-dependent regulation of autophagy.
  Journal
Small GTPases 9:399-408 (2018)
DOI:10.1080/21541248.2016.1240495
Reference
  Authors
Webster CP, Smith EF, Bauer CS, Moller A, Hautbergue GM, Ferraiuolo L, Myszczynska MA, Higginbottom A, Walsh MJ, Whitworth AJ, Kaspar BK, Meyer K, Shaw PJ, Grierson AJ, De Vos KJ
  Title
The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy.
  Journal
EMBO J 35:1656-76 (2016)
DOI:10.15252/embj.201694401
Reference
  Authors
Yang M, Liang C, Swaminathan K, Herrlinger S, Lai F, Shiekhattar R, Chen JF
  Title
A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy.
  Journal
Sci Adv 2:e1601167 (2016)
DOI:10.1126/sciadv.1601167
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