KEGG   NETWORK: N01198
Entry
N01198                      Network                                

Name
Scrapie conformation PrPSc to PERK-ATF4 signaling pathway
Definition
PRNP* -| BIP -| EIF2AK3 -> EIF2S1 -> ATF4 => DDIT3
  Expanded
5621v1 -| 3309 -| 9451 -> 1965 -> 468 => 1649
Class
nt06412 Unfolded protein response (UPR) signaling
nt06465 Prion disease
Type
Variant
Pathway
hsa05020  Prion disease
Disease
H00061  Prion disease
Gene
5621  PRNP; prion protein
3309  HSPA5; heat shock protein family A (Hsp70) member 5
9451  EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3
1965  EIF2S1; eukaryotic translation initiation factor 2 subunit alpha
468  ATF4; activating transcription factor 4
1649  DDIT3; DNA damage inducible transcript 3
Variant
5621v1 (PRNP*)  PRNP scrapie conformation
Reference
  Authors
Hughes D, Mallucci GR
  Title
The unfolded protein response in neurodegenerative disorders - therapeutic modulation of the PERK pathway.
  Journal
FEBS J 286:342-355 (2019)
DOI:10.1111/febs.14422
Reference
  Authors
Halliday M, Hughes D, Mallucci GR
  Title
Fine-tuning PERK signaling for neuroprotection.
  Journal
J Neurochem 142:812-826 (2017)
DOI:10.1111/jnc.14112
Reference
  Authors
Hughes D, Halliday M
  Title
What Is Our Current Understanding of PrP(Sc)-Associated Neurotoxicity and Its Molecular Underpinnings?
  Journal
Pathogens 6:E63 (2017)
DOI:10.3390/pathogens6040063
Reference
  Authors
Mays CE, Soto C
  Title
The stress of prion disease.
  Journal
Brain Res 1648:553-560 (2016)
DOI:10.1016/j.brainres.2016.04.009
Reference
  Authors
Song Z, Zhao D, Yang L
  Title
Molecular mechanisms of neurodegeneration mediated by dysfunctional subcellular organelles in transmissible spongiform encephalopathies.
  Journal
Acta Biochim Biophys Sin (Shanghai) 45:452-64 (2013)
DOI:10.1093/abbs/gmt014
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