KEGG   NETWORK: N01201
Entry
N01201                      Network                                

Name
Scrapie conformation PrPSc to VGCC-Ca2+ -apoptotic pathway
Definition
PRNP* -| VGCC(N,L-type) -> Ca2+
  Expanded
5621v1 -| (774,775,776,778,779) -> C00076
Class
nt06410 Calcium signaling
nt06465 Prion disease
Type
Variant
Pathway
hsa05020  Prion disease
Disease
H00061  Prion disease
Gene
5621  PRNP; prion protein
774  CACNA1B; calcium voltage-gated channel subunit alpha1 B
775  CACNA1C; calcium voltage-gated channel subunit alpha1 C
776  CACNA1D; calcium voltage-gated channel subunit alpha1 D
778  CACNA1F; calcium voltage-gated channel subunit alpha1 F
779  CACNA1S; calcium voltage-gated channel subunit alpha1 S
Variant
5621v1 (PRNP*)  PRNP scrapie conformation
Metabolite
C00076  Calcium cation
Reference
  Authors
Ureshino RP, Erustes AG, Bassani TB, Wachilewski P, Guarache GC, Nascimento AC, Costa AJ, Smaili SS, Pereira GJDS
  Title
The Interplay between Ca(2+) Signaling Pathways and Neurodegeneration.
  Journal
Int J Mol Sci 20:E6004 (2019)
DOI:10.3390/ijms20236004
Reference
  Authors
Thellung S, Florio T, Villa V, Corsaro A, Arena S, Amico C, Robello M, Salmona M, Forloni G, Bugiani O, Tagliavini F, Schettini G
  Title
Apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in rat cerebellar granule cells treated with the prion protein fragment  106-126.
  Journal
Neurobiol Dis 7:299-309 (2000)
DOI:10.1006/nbdi.2000.0301
Reference
  Authors
Sandberg MK, Wallen P, Wikstrom MA, Kristensson K
  Title
Scrapie-infected GT1-1 cells show impaired function of voltage-gated N-type calcium channels (Ca(v) 2.2) which is ameliorated by quinacrine treatment.
  Journal
Neurobiol Dis 15:143-51 (2004)
DOI:10.1016/j.nbd.2003.09.006
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