KEGG   NETWORK: N01202
Entry
N01202                      Network                                

Name
Oligomeric conformation PrPc to anterograde axonal transport
Definition
PRNP* -> (GSK3B,CK2) -| (KIF5+KLC)
  Expanded
5621v2 -> (2932,1457,1459,1460,283106) -| ((3798,3799,3800)+(3831,64837,147700,89953))
Class
nt06419 Microtubule-based transport
nt06465 Prion disease
Type
Variant
Pathway
hsa05020  Prion disease
Disease
H00061  Prion disease
Gene
5621  PRNP; prion protein
2932  GSK3B; glycogen synthase kinase 3 beta
1457  CSNK2A1; casein kinase 2 alpha 1
1459  CSNK2A2; casein kinase 2 alpha 2
1460  CSNK2B; casein kinase 2 beta
283106  CSNK2A3; casein kinase 2 alpha 3
3798  KIF5A; kinesin family member 5A
3799  KIF5B; kinesin family member 5B
3800  KIF5C; kinesin family member 5C
3831  KLC1; kinesin light chain 1
64837  KLC2; kinesin light chain 2
147700  KLC3; kinesin light chain 3
89953  KLC4; kinesin light chain 4
Variant
5621v2 (PRNP*)  PRNP oligomeric conformation
Reference
  Authors
Zamponi E, Pigino GF
  Title
Protein Misfolding, Signaling Abnormalities and Altered Fast Axonal Transport: Implications for Alzheimer and Prion Diseases.
  Journal
Front Cell Neurosci 13:350 (2019)
DOI:10.3389/fncel.2019.00350
Reference
  Authors
Zamponi E, Buratti F, Cataldi G, Caicedo HH, Song Y, Jungbauer LM, LaDu MJ, Bisbal M, Lorenzo A, Ma J, Helguera PR, Morfini GA, Brady ST, Pigino GF
  Title
Prion protein inhibits fast axonal transport through a mechanism involving casein kinase 2.
  Journal
PLoS One 12:e0188340 (2017)
DOI:10.1371/journal.pone.0188340
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