KEGG   NETWORK: N01203
Entry
N01203                      Network                                

Name
Scrapie conformation PrPSc to Notch singling pathway
Definition
PRNP* -> NOTCH1
  Expanded
5621v1 -> 4851
Class
nt06465 Prion disease
Type
Variant
Pathway
hsa05020  Prion disease
Disease
H00061  Prion disease
Gene
5621  PRNP; prion protein
4851  NOTCH1; notch receptor 1
Variant
5621v1 (PRNP*)  PRNP scrapie conformation
Reference
  Authors
Ishikura N, Clever JL, Bouzamondo-Bernstein E, Samayoa E, Prusiner SB, Huang EJ, DeArmond SJ
  Title
Notch-1 activation and dendritic atrophy in prion disease.
  Journal
Proc Natl Acad Sci U S A 102:886-91 (2005)
DOI:10.1073/pnas.0408612101
Reference
  Authors
Dearmond SJ, Bajsarowicz K
  Title
PrPSc accumulation in neuronal plasma membranes links Notch-1 activation to dendritic degeneration in prion diseases.
  Journal
Mol Neurodegener 5:6 (2010)
DOI:10.1186/1750-1326-5-6
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