KEGG   NETWORK: N01205
Entry
N01205                      Network                                

Name
Scrapie conformation PrPSc to PRNP-PI3K-NOX2 signaling pathway
Definition
PRNP* -> CAV -> FYN -> PI3K -> PRKCD -> NOX2 -> ROS
  Expanded
5621v1 -> (857,858,859) -> 2534 -> (5290,5291,5293) -> 5580 -> ((1536+1535+4689+653361+4688+(5879,5880)) -> (C00027,C00704)
Class
nt06415 PI3K signaling
nt06465 Prion disease
Type
Variant
Pathway
hsa05020  Prion disease
Disease
H00061  Prion disease
Gene
5621  PRNP; prion protein
857  CAV1; caveolin 1
858  CAV2; caveolin 2
859  CAV3; caveolin 3
2534  FYN; FYN proto-oncogene, Src family tyrosine kinase
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
5580  PRKCD; protein kinase C delta
1536  CYBB; cytochrome b-245 beta chain
1535  CYBA; cytochrome b-245 alpha chain
4689  NCF4; neutrophil cytosolic factor 4
653361  NCF1; neutrophil cytosolic factor 1
4688  NCF2; neutrophil cytosolic factor 2
5879  RAC1; Rac family small GTPase 1
5880  RAC2; Rac family small GTPase 2
Variant
5621v1 (PRNP*)  PRNP scrapie conformation
Metabolite
C00027  Hydrogen peroxide
C00704  Superoxide
Reference
  Authors
Schneider B, Pietri M, Pradines E, Loubet D, Launay JM, Kellermann O, Mouillet-Richard S
  Title
Understanding the neurospecificity of Prion protein signaling.
  Journal
Front Biosci (Landmark Ed) 16:169-86 (2011)
DOI:10.2741/3682
Reference
  Authors
Hirsch TZ, Hernandez-Rapp J, Martin-Lanneree S, Launay JM, Mouillet-Richard S
  Title
PrP(C) signalling in neurons: from basics to clinical challenges.
  Journal
Biochimie 104:2-11 (2014)
DOI:10.1016/j.biochi.2014.06.009
Reference
  Authors
Marella M, Gaggioli C, Batoz M, Deckert M, Tartare-Deckert S, Chabry J
  Title
Pathological prion protein exposure switches on neuronal mitogen-activated protein kinase pathway resulting in microglia recruitment.
  Journal
J Biol Chem 280:1529-34 (2005)
DOI:10.1074/jbc.M410966200
Reference
  Authors
Didonna A
  Title
Prion protein and its role in signal transduction.
  Journal
Cell Mol Biol Lett 18:209-30 (2013)
DOI:10.2478/s11658-013-0085-0
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