KEGG   REACTION: R00428
Entry
R00428                      Reaction                               
Name
GTP 8,9-hydrolase
Definition
GTP + H2O <=> Formamidopyrimidine nucleoside triphosphate
Equation
C00044 + C00001 <=> C05922
Comment
the first step of four-step reaction (see R00424, R00428+R05046+R05048+R04639)
subsequently R05046
Reaction class
RC00294  C00044_C05922
Enzyme
3.5.4.16
Pathway
rn00790  Folate biosynthesis
rn01100  Metabolic pathways
Module
M00126  Tetrahydrofolate biosynthesis, GTP => THF
M00841  Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF
M00842  Tetrahydrobiopterin biosynthesis, GTP => BH4
M00843  L-threo-Tetrahydrobiopterin biosynthesis, GTP => L-threo-BH4
Orthology
K01495  GTP cyclohydrolase IA [EC:3.5.4.16]
K09007  GTP cyclohydrolase IB [EC:3.5.4.16]
K22391  GTP cyclohydrolase I [EC:3.5.4.16]
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