KEGG   REACTION: R01934Help
Entry
R01934                      Reaction                               

Name
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating);
homoisocitrate:NAD+ oxidoreductase (decarboxylating)
Definition
Homoisocitrate + NAD+ <=> 2-Oxoadipate + CO2 + NADH + H+
Equation
Comment
two-step reaction (see R04862+R01936), reversible
Reaction class
RC00001  C00003_C00004
RC00114  C00322_C05662
Enzyme
1.1.1.87        1.1.1.286
Pathway
rn00300  Lysine biosynthesis
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01130  Biosynthesis of antibiotics
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Orthology
K05824  homoisocitrate dehydrogenase [EC:1.1.1.87]
K10978  methanogen homoisocitrate dehydrogenase [EC:1.1.1.87 1.1.1.-]
K17753  isocitrate--homoisocitrate dehydrogenase [EC:1.1.1.286]
Reference
1  [PMID:4395693]
  Authors
Rowley B, Tucci AF.
  Title
Homoisocitric dehydrogenase from yeast.
  Journal
Arch Biochem Biophys 141:499-510 (1970)
DOI:10.1016/0003-9861(70)90167-0
Reference
2  [PMID:5808337]
  Authors
Chilina K, Thomas U, Tucci AF, McMichael KD, Stevens CM.
  Title
Synthesis and absolute configuration of the isomers of homoisocitric acid (1-hydroxy-1,2,4-butanetricarboxylic acid) and the stereochemistry of lysine biosynthesis.
  Journal
Biochemistry 8:2846-55 (1969)
Other DBs
RHEA: 11903
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