KEGG   REACTION: R05640
Entry
R05640                      Reaction                               
Name
lanosterol,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (14-methyl cleaving)
Definition
Lanosterol + 3 [Reduced NADPH---hemoprotein reductase] + 3 Oxygen <=> 4,4-Dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + Formate + 3 [Oxidized NADPH---hemoprotein reductase] + 4 H2O
Equation
C01724 + 3 C03024 + 3 C00007 <=> C11455 + C00058 + 3 C03161 + 4 C00001
Reaction class
RC01442  C01724_C11455
Enzyme
Pathway
rn00100  Steroid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00101  Cholesterol biosynthesis, FPP => cholesterol
M00102  Ergocalciferol biosynthesis, FPP => ergosterol/ergocalciferol
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.154
     R05640  Lanosterol + 3 [Reduced NADPH---hemoprotein reductase] + 3 Oxygen <=> 4,4-Dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + Formate + 3 [Oxidized NADPH---hemoprotein reductase] + 4 H2O
IUBMB reaction hierarchy [BR:br08202]
 1. Oxidoreductase reactions
  1.14.14.154
   R12118  14alpha-Methylsteroid <=> Delta14-Steroid
    R05640  Lanosterol <=> 4,4-Dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
Orthology
K05917  sterol 14alpha-demethylase [EC:1.14.14.154 1.14.15.36]
Other DBs
RHEA: 25289
LinkDB

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