KEGG   PATHWAY: acs04115
Entry
acs04115                    Pathway                                

Name
p53 signaling pathway - Anolis carolinensis (green anole)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
acs04115  p53 signaling pathway
acs04115

Organism
Anolis carolinensis (green anole) [GN:acs]
Gene
100556408  serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
100560063  atm; ATM serine/threonine kinase [KO:K04728] [EC:2.7.11.1]
100561948  atr; ATR serine/threonine kinase [KO:K06640] [EC:2.7.11.1]
100564808  chek1; checkpoint kinase 1 [KO:K02216] [EC:2.7.11.1]
100555490  gorab; golgin, RAB6 interacting [KO:K19748]
100556723  mdm2; MDM2 proto-oncogene [KO:K06643] [EC:2.3.2.27]
100567197  mdm4; MDM4, p53 regulator [KO:K10127]
103282543  cellular tumor antigen p53 [KO:K04451]
100555337  cdkn1a; cyclin dependent kinase inhibitor 1A [KO:K06625]
100563772  ccnd1; cyclin D1 [KO:K04503]
100566165  ccnd3; cyclin D3 [KO:K10152]
100559515  cdk4; cyclin dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100558412  cdk6; cyclin dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
100553527  ccne1; cyclin E1 [KO:K06626]
100563792  ccne2; cyclin E2 [KO:K06626]
100555545  cdk2; cyclin dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
100555819  sfn; stratifin [KO:K06644]
100560141  rprm; reprimo, TP53 dependent G2 arrest mediator candidate [KO:K10128]
103277771  reprimo-like protein [KO:K10128]
100557278  ccnb1; cyclin B1 [KO:K05868]
100555671  cntd2; cyclin N-terminal domain containing 2 [KO:K21770]
100562632  cdk1; cyclin dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
100554443  gadd45a; growth arrest and DNA damage inducible alpha [KO:K04402]
100567812  gadd45g; growth arrest and DNA damage inducible gamma [KO:K04402]
100556906  gtse1; G2 and S-phase expressed 1 [KO:K10129]
100551688  fas; Fas cell surface death receptor [KO:K04390]
100564298  pidd1; p53-induced death domain protein 1 [KO:K10130]
100559769  tumor necrosis factor receptor superfamily member 26 [KO:K04722]
103281217  tnfrsf10b; TNF receptor superfamily member 10b [KO:K04722]
100563997  bid; BH3 interacting domain death agonist [KO:K04726]
100561911  apoptosis regulator BAX [KO:K02159]
100562834  bax; apoptosis regulator BAX [KO:K02159]
103280258  pmaip1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
103277695  siva1; SIVA1 apoptosis inducing factor [KO:K22744]
100561922  bcl2l1; BCL2 like 1 [KO:K04570]
100564886  bcl2; apoptosis regulator Bcl-2 [KO:K02161]
100566575  ei24; EI24, autophagy associated transmembrane protein [KO:K10134]
100553901  shisa5; shisa family member 5 [KO:K10135]
100564136  p53 apoptosis effector related to PMP-22 [KO:K10136]
100563938  perp; PERP, TP53 apoptosis effector [KO:K10136]
100564507  zmat3; zinc finger matrin-type 3 [KO:K10137]
100555807  siah1; siah E3 ubiquitin protein ligase 1 [KO:K04506] [EC:2.3.2.27]
100559887  cytochrome c iso-1/iso-2 [KO:K08738]
100560655  cytochrome c [KO:K08738]
100556318  apaf1; apoptotic peptidase activating factor 1 [KO:K02084]
100560103  casp9; caspase 9 [KO:K04399] [EC:3.4.22.62]
100563931  casp3; caspase 3 [KO:K02187] [EC:3.4.22.56]
100551529  aifm2; apoptosis inducing factor, mitochondria associated 2 [KO:K22745]
100565907  igfbp3; insulin like growth factor binding protein 3 [KO:K10138]
100566682  igf1; insulin like growth factor 1 [KO:K05459]
100558317  serpine1; serpin family E member 1 [KO:K03982]
100561578  adgrb1; adhesion G protein-coupled receptor B1 [KO:K04596]
100559286  cd37; CD37 molecule [KO:K06509]
100555967  cd82; CD82 molecule [KO:K06509]
100552734  thbs1; thrombospondin 1 [KO:K16857]
100559144  uncharacterized LOC100559144 [KO:K10139]
100554400  ddb2; damage specific DNA binding protein 2 [KO:K10140]
100566226  rrm2b; ribonucleotide reductase regulatory TP53 inducible subunit M2B [KO:K10808] [EC:1.17.4.1]
100568029  rrm2; ribonucleotide reductase regulatory subunit M2 [KO:K10808] [EC:1.17.4.1]
100562336  sesn1; sestrin 1 [KO:K10141]
103282094  sestrin-3 [KO:K10141]
100557159  sesn3; sestrin 3 [KO:K10141]
100565147  sesn2; sestrin 2 [KO:K20394]
100552870  pten; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100552562  tsc2; tuberous sclerosis 2 [KO:K07207]
100561470  steap3; STEAP3 metalloreductase [KO:K10142] [EC:1.16.1.-]
100553769  rfwd2; ring finger and WD repeat domain 2 [KO:K10143] [EC:2.3.2.27]
100555513  ccng1; cyclin G1 [KO:K10145]
100556642  ccng2; cyclin G2 [KO:K10146]
100558697  ppm1d; protein phosphatase, Mg2+/Mn2+ dependent 1D [KO:K10147] [EC:3.1.3.16]
100554137  tp73; tumor protein p73 [KO:K10148]
Reference
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Related
pathway
acs04110  Cell cycle
acs04210  Apoptosis
acs04218  Cellular senescence
KO pathway
ko04115   
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