KEGG   PATHWAY: adh03440
Entry
adh03440                    Pathway                                

Name
Homologous recombination - Aeromonas dhakensis
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
adh03440  Homologous recombination
adh03440

Other DBs
GO: 0000724
Organism
Aeromonas dhakensis [GN:adh]
Gene
CK627_09360  single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
CK627_02030  single-stranded DNA-binding protein [KO:K03111]
CK627_03895  DNA replication/repair protein RecF [KO:K03629]
CK627_07935  recO; DNA repair protein RecO [KO:K03584]
CK627_13550  recombination protein RecR [KO:K06187]
CK627_00800  recA; recombinase RecA [KO:K03553]
CK627_04740  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
CK627_00230  Holliday junction branch migration protein RuvA [KO:K03550] [EC:3.6.4.12]
CK627_00225  Holliday junction branch migration DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
CK627_19645  crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.22.4]
CK627_05210  ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
CK627_02130  recB; exodeoxyribonuclease V subunit beta [KO:K03582] [EC:3.1.11.5]
CK627_02135  recC; exodeoxyribonuclease V subunit gamma [KO:K03583] [EC:3.1.11.5]
CK627_02125  recD; exodeoxyribonuclease V subunit alpha [KO:K03581] [EC:3.1.11.5]
CK627_20195  DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
CK627_03900  DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
CK627_14830  DNA polymerase III subunit gamma/tau [KO:K02343] [EC:2.7.7.7]
CK627_09480  holA; DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
CK627_15050  holB; DNA polymerase III subunit delta' [KO:K02341] [EC:2.7.7.7]
CK627_18230  DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
CK627_13965  DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
CK627_00725  DNA polymerase III subunit chi [KO:K02339] [EC:2.7.7.7]
CK627_07500  hypothetical protein [KO:K02344] [EC:2.7.7.7]
CK627_03245  primosomal protein N' [KO:K04066] [EC:3.6.4.-]
CK627_21955  hypothetical protein [KO:K02317]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   
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