KEGG   PATHWAY: aea03440
Entry
aea03440                    Pathway                                

Name
Homologous recombination - Aeromonas sp. ASNIH3
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
aea03440  Homologous recombination
aea03440

Other DBs
GO: 0000724
Organism
Aeromonas sp. ASNIH3 [GN:aea]
Gene
C2U39_05435  single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
C2U39_23625  single-stranded DNA-binding protein [KO:K03111]
C2U39_02035  single-stranded DNA-binding protein [KO:K03111]
C2U39_15365  single-stranded DNA-binding protein [KO:K03111]
C2U39_22240  DNA replication and repair protein RecF [KO:K03629]
C2U39_03680  recO; DNA repair protein RecO [KO:K03584]
C2U39_09025  recombination protein RecR [KO:K06187]
C2U39_19700  recA; recombinase RecA [KO:K03553]
C2U39_21160  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
C2U39_18670  Holliday junction branch migration protein RuvA [KO:K03550] [EC:3.6.4.12]
C2U39_18665  Holliday junction branch migration DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
C2U39_16005  crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.22.4]
C2U39_00650  ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
C2U39_05995  ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
C2U39_19950  recB; exodeoxyribonuclease V subunit beta [KO:K03582] [EC:3.1.11.5]
C2U39_19955  recC; exodeoxyribonuclease V subunit gamma [KO:K03583] [EC:3.1.11.5]
C2U39_19945  exodeoxyribonuclease V subunit alpha [KO:K03581] [EC:3.1.11.5]
C2U39_16510  DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
C2U39_22235  DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
C2U39_10680  DNA polymerase III subunit gamma/tau [KO:K02343] [EC:2.7.7.7]
C2U39_05520  holA; DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
C2U39_10955  holB; DNA polymerase III subunit delta' [KO:K02341] [EC:2.7.7.7]
C2U39_09860  3'-5' exonuclease [KO:K02342] [EC:2.7.7.7]
C2U39_18685  3'-5' exonuclease [KO:K02342] [EC:2.7.7.7]
C2U39_07380  DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
C2U39_22870  3'-5' exonuclease [KO:K02342] [EC:2.7.7.7]
C2U39_24010  3'-5' exonuclease [KO:K02342] [EC:2.7.7.7]
C2U39_19625  DNA polymerase III subunit chi [KO:K02339] [EC:2.7.7.7]
C2U39_18365  hypothetical protein [KO:K02344] [EC:2.7.7.7]
C2U39_20880  primosomal protein N' [KO:K04066] [EC:3.6.4.-]
C2U39_04220  hypothetical protein [KO:K02317]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   
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